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Aceclofenac 100 mg, Paracetamol 325 mg, Serratiopeptidase 10 mg Tablets

This combination offers the advantage of the peripheral effects of aceclofenac, the central effect of paracetamol and pain relief with the tissue repair effects of serratiopeptidase for pain management.

What is SMACLIF-Forte and What it is Used For?
SMACLIF-Forte is a combination of Aceclofenac, Paracetamol & Serratiopeptidase. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti- inflammatory, analgesic, and antipyretic activities. Paracetamol, also known as Acetaminophen, is commonly used for its analgesic and antipyretic effects. Serratiopeptidase is a proteolytic enzyme (protease) produced by Enterobacterium Serratia sp. E-15 used in the prevention of pain and swelling.

Indications and Usage

SMACLIF-Forte is used in adults and children to treat the following infections:
  • For relief of mild to moderate pain.
  • Pain and fever due to upper respiratory tract infections.
  • Spondylitis
  • Back and Joint Pain.
  • Headache


Mechanism of Action
It inhibits PGE2 at site of inflammation and neutrophils and thereby helps in pain relief.

Pharmacokinetic Properties
Absorption: After oral administration, aceclofenac is rapidly and completely absorbed as unchanged drug. Peak plasma concentrations are reached approximately 1.25- 3.00 hours following ingestion.
Distribution: Aceclofenac penetrates into the synovial fluid, where the concentrations reach approximately 57% of those in plasma. The volume of distribution is approximately 25 L. Aceclofenac is highly protein-bound (>99%). Aceclofenac circulates mainly as unchanged drug.
Metabolism: 4'hydroxyaceclofenac is the main metabolite detected in plasma.
Elimination: The mean plasma elimination half-life is around 4 hours. Approximately twothirds of the administered dose is excreted via the urine, mainly as hydroxymetabolites.
Absorption: Paracetamol is well absorbed by the oral route. The plasma half-life is about 2 hours.
Distribution Plasma protein binding is negligible at the usual therapeutic concentration, but increases with increasing concentrations. Acetaminophen is, relatively, uniformly distributed throughout most body fluids. The plasma half-life is (t1/2) 2-3 hours and the effect after an oral dose lasts for 3-5 hours.
Metabolism: Paracetamol is primarily metabolized in the liver by conjugation to glucuronide and sulphate. A small amount (about 3-10% of a therapeutic dose) is metabolized by oxidation and the reactive intermediate metabolite thus formed is bound preferentially to the liver glutathione and excreted as cysteine and mercapturic acid conjugates.
Elimination: Excretion occurs via the kidneys. Of a therapeutic dose, 2-3% is excreted unchanged, 80-90% as glucuronide and sulphate, and a smaller amount as cystein and mercapturic acid derivatives.
Absorption: After oral administration, serratiopeptidase is almost totally absorbed from the gastrointestinal (GI) tract.
Distribution: Serratiopeptidase binds to alpha-2 macroglobulin in the blood and produces an enzyme activity in the blood circulation. It shows a steep rise in concentration at the site of injury and inflammation.
Metabolism: Metabolism of serratiopeptidase takes place in the liver.
Excretion: The metabolites of serratiopeptidase are excreted through the urine and faeces.


Disclaimer:To be taken only after consulting with the doctor.


Patients sensitive to aceclofenac, paracetamol & serratiopeptidase.
Contraindicated in patients with severe ulcer gastrointestinal bleeding and hypersensitivity.
Aceclofenac and Serratiopeptidase is contraindicated in patients with asthma, renal or hepatic disorders, hypertension and porphyria.

Side Effects

Aceclofenac, Paracetamol and Serratiopeptidase may cause side effects.
● Diarrhea
● Upset stomach
● Vomiting
● Mild skin rash


Store in a cool, dry place. Protect from light.

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