Amoxicillin is a semi synthetic penicillin with a broad spectrum bactericidal activity, and has good oral absorption.It acts through the inhibition of biosynthesis of cell wall.
Potassium Clavunate It act as a inhibitor of Β-lactamases of Gram +ve and Gram -ve pathogenic bacteria.
Has a protective effect on Amoxicillin Clavulanic acid when combined with Amoxicillin extends the antibacterial spectrum of Amoxicillin to include organisms resistant to Amoxicillin and other beta-lactam antibiotics, It has been demonstrated by recent studies that Amoxycillin and potassium clavunate shows significantly better symptoms relief with the modest improvement of Upper and lower respiratory tract infections.
- Upper and lower respiratory tract infection.
- Otitis Media (inflammation of the middle ear).
- Acute Sinusitis.
- Acute exacerbation of chronic bronchitis.
- Urinary tract infection.
Mechanism of Action:
- Penicillin-like antibiotic Amoxicillin works by stopping the growth of bacteria.
- Potassium clavunate works by preventing bacteria from destroying amoxicillin.
Pharmacokinetics:Clavulanic acid binds and inhibits beta-lactamases that inactivate amoxicillin resulting in amoxicillin having an expanded spectrum of activity. Amoxicillin inhibits bacterial cell wall synthesis by binding to one or more of the penicillin- binding proteins which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.
- Diarrhea/loose stools