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Ceftriaxone 1000 mg Injections


Ceftriaxone Sodium is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad-spectrum activity against Gram-positive and Gram-negative bacteria.

Indications

  • Treatment of infections of lower respiratory tract.
  • Infections of skin and skin structures.
  • Infections of bone and joint.
  • Urinary tract infections
  • Treatment of pelvic inflammatory disease.
  • Intra-abdominal infections.
  • Gonorrhea (uncomplicated.)
  • Meningitis.
  • Bacterial septicemia.
  • Septicemia caused by susceptible microorganisms.
  • Preoperative prophylaxis.
  • Neuroprotective properties in a number of neurological disorders, including spinal muscular atrophy and amyotrophic lateral sclerosis.

Rationale of Combination

Product Description:
Ceftriaxone injection is used to treat certain infections caused by bacteria such as gonorrhea (a sexually transmitted disease), pelvic inflammatory disease (infection of the female reproductive organs that may cause infertility), meningitis (infection of the membranes that surround the brain and spinal cord), and infections of the lungs, ears, skin, urinary tract, blood, bones, joints, and abdomen. Ceftriaxone injection is also sometimes given before certain types of surgery to prevent infections that may develop after the operation. Ceftriaxone injection is in a class of medications called cephalosporin antibiotics.

Pharmacology

Pharmacokinetics:
Ceftriaxone is completely absorbed, its T max is 2 to 3 h. Ceftriaxone is 85% to 95% protein bound (concentration dependent) and it also crosses the blood-placenta barrier. 33% to 67% is excreted in the urine as unchanged drug, and the remainder in the bile and ultimately in the feces as inactive compounds and its half-life is 5.8 to 8.7 h.

Adverse Effects

  • Black, tarry stools.
  • Painful or difficult urination.
  • Sores, ulcers, or white spots on the lips or in the mouth.
  • Unusual bleeding or bruising.
  • Unusual tiredness or weakness.

Contraindications

Hypersensitivity to cephalosporins; hyperbilirubinemic neonates (28 days or younger); concomitant use with calcium-containing IV solutions, including continuous calcium-containing infusions, such as parenteral nutrition in neonates; hypersensitivity to corn products (dextrose-containing solutions only).

Drug Interactions

Some products that may interact with this drug include: aminoglycoside antibiotics (e.g., tobramycin, gentamicin), "blood thinners" (e.g., warfarin), chloramphenicol, live bacterial vaccines, calcium-containing IV fluids. Although most antibiotics probably do not affect hormonal birth control such as pills, patch, or ring, some antibiotics may decrease their effectiveness. This could cause pregnancy. Examples include rifamycins such as rifampin or rifabutin.

Contact Details

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