ANARIZIN-D is a complete antiemetic and antivertigo drug. It is a combination of Domperidone & Cinnarizine that takes care of the symptoms of nausea and vomiting as well as the root cause of motion sickness respectively.
ANARIZIN-D is antiemetic and antivertigo drug. Domperidone is a selective peripheral dopamine antagonist at the D2 receptor. It acts on D2 receptors at the CETZ and stomach but it does not readily cross blood brain barrier (BBB). It is structurally related to butyrophenones with antiemetic and gastroprokinetic properties. Domperidone Maleate increases the lower oesophageal sphincter (LES) pressure, promotes oesophageal peristalsis increases gastric emptying time and frequency, amplitude and durations of duodenal contractions. Cinnarizine has a centrally acting antihistamine (H1) effect and a calcium channel antagonist. Cinnarizine depresses labyrinth and acts as a peripheral vasodilator. Cinnarizine also reduces blood viscosity but does not have any effect on blood pressure and heart rate.
WHAT IS ANARIZIN-D AND WHAT IT IS USED FOR?
Why is this medication prescribed?ANARIZIN-D is a combination of Cinnarizine 20mg and Domperidone 15mg. This combination of Cinnarizine and Domperidone would be ideal for the management of vestibular disorders prophylaxis and control of motion sickness and nausea & vomiting of varies aetiologies.
Indications and Usage
- Cinnarizine is predominantly used to treat nausea and vomiting associated with motion sickness, vertigo or Cogan's syndrome. In fact, it is one of only a select few drugs that has shown a beneficial effect in the chronic treatment of the vertigo and tinnitus, associated with Meniere's disease.
- Vestibular disorders
- Prophylaxis and control of Motion sickness
- Nausea and vomiting of varied aetiology.
Cinnarizine is well tolerated; commonly reported side effects were sedation.gastric irritation, rashes and drowsiness.
Central effects such as extra pyramidal reactions or drowsiness may be lower.
Caution when used during pregnancy
Cinnarizine + Domperidone and Lactation
Caution when used during lactation
Cinnarizine + Domperidone and Other Contraindications
Hypersensitivity. Parkinson's disease. GI haemorrhage, obstruction and perforation, patients with prolactin releasing pituitary hormone or chronic admin or for prophylaxis of postoperative nausea and vomiting. Neonates, children.
Pharmacodynamics:Cinnarizine has antihistaminic, sedative and calcium channel blocking activity. Cinnarizine by virtue of its calcium channel blocking activity relaxes vascular smooth muscles. It has been found to modulate calcium fluxes and attenuates vasoconstrictor action probably by its action on calcium movement. It improves blood flow to labyrinth and brainstem, also acts as labyrinth sedative. Domperidone possesses both prokinetic and antiemetic properties. Domperidone is a dopaminergic and it is postulated that it causes antiemetic action by blocking dopamine receptors, also it increases gastric motility. Domperidone crosses the blood brain barrier to only a limited extent, and it causes extra pyramidal side effects very rarely.
Pharmacokinetics:Cinnarizine is absorbed from the gastro intestinal tract, peak plasma concentrations occurring 2 to 4 hrs after oral administration. It undergoes metabolism and has a half life of 3 to 6 hrs. Cinnirazine is excreted mainly in the feces as unchanged drug and in urine mainly as its metabolites. Domperidone bioavailability is increased when it is administered after food compared to before food. Peak plasma is reached within 30 minutes following the administration of dose, 90% is bound to plasma protein and has a half life is 7.5 hrs. About 30% of the dose is excreted in urine within 24 hrs almost entirely as metabolites and the remaining as feces over several days.
● Domperidone reduces absorption of oral digoxin. It increases absorption of aspirin, paracetamol and oral diazepam.
● Enhances CNS depression by phenothiazine.
● Antimuscarinic agents and opioids antagonise GI effects. Prolongs suxamethonium-induced neuromuscular blockade.
● Patients should not operate hazardous machinery or drive motor vehicles or perform potentially hazardous tasks where loss of concentration may lead to accidents.
OralThis is Preferred Dosage:
Adult: Each tablet contains cinnarizine 20 mg and domperidone 15 mg: 1 tablet taken 1-2 hours before travel and 1 tablet every 6 hours during journey if necessary.
Disclaimer:To be taken only after consulting with the doctor.