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ANARIZIN-D

₹45

Cinnarizine 20 mg, Domperidone 15 mg Tablets


ANARIZIN-D is a complete antiemetic and antivertigo drug. It is a combination of Domperidone & Cinnarizine that takes care of the symptoms of nausea and vomiting as well as the root cause of motion sickness respectively.

WHAT IS ANARIZIN-D AND WHAT IT IS USED FOR?

ANARIZIN-D is antiemetic and antivertigo drug. Domperidone is a selective peripheral dopamine antagonist at the D2 receptor. It acts on D2 receptors at the CETZ and stomach but it does not readily cross blood brain barrier (BBB). It is structurally related to butyrophenones with antiemetic and gastroprokinetic properties. Domperidone Maleate increases the lower oesophageal sphincter (LES) pressure, promotes oesophageal peristalsis increases gastric emptying time and frequency, amplitude and durations of duodenal contractions. Cinnarizine has a centrally acting antihistamine (H1) effect and a calcium channel antagonist. Cinnarizine depresses labyrinth and acts as a peripheral vasodilator. Cinnarizine also reduces blood viscosity but does not have any effect on blood pressure and heart rate.
Why is this medication prescribed?
ANARIZIN-D is a combination of Cinnarizine 20mg and Domperidone 15mg. This combination of Cinnarizine and Domperidone would be ideal for the management of vestibular disorders prophylaxis and control of motion sickness and nausea & vomiting of varies aetiologies.

Indications and Usage

  • Cinnarizine is predominantly used to treat nausea and vomiting associated with motion sickness, vertigo or Cogan's syndrome. In fact, it is one of only a select few drugs that has shown a beneficial effect in the chronic treatment of the vertigo and tinnitus, associated with Meniere's disease.
  • Vestibular disorders
  • Prophylaxis and control of Motion sickness
  • Nausea and vomiting of varied aetiology.

Side Effects

Cinnarizine is well tolerated; commonly reported side effects were sedation.gastric irritation, rashes and drowsiness.
Central effects such as extra pyramidal reactions or drowsiness may be lower.

Contraindications

Cinnarizine + Domperidone and Pregnancy
Caution when used during pregnancy

Cinnarizine + Domperidone and Lactation
Caution when used during lactation

Cinnarizine + Domperidone and Other Contraindications
Hypersensitivity. Parkinson's disease. GI haemorrhage, obstruction and perforation, patients with prolactin releasing pituitary hormone or chronic admin or for prophylaxis of postoperative nausea and vomiting. Neonates, children.

Pharmacology

Cinnarizine has Ca channel blocking activity selective for arterial smooth muscles. It has some antihistamine activity. Cinnarizine acts as a labyrinthine sedative. It also improves microcirculation by reducing ischaemia-induced blood viscosity. Domperidone is a peripheral dopamine-receptor blocker. It increases both the oesophageal peristalsis and the lower oesophageal sphincter pressure. It also increases gastric motility and peristalsis, and enhances gastroduodenal coordination, thus facilitating gastric emptying and decreasing small bowel transit time.
Pharmacodynamics:
Cinnarizine has antihistaminic, sedative and calcium channel blocking activity. Cinnarizine by virtue of its calcium channel blocking activity relaxes vascular smooth muscles. It has been found to modulate calcium fluxes and attenuates vasoconstrictor action probably by its action on calcium movement. It improves blood flow to labyrinth and brainstem, also acts as labyrinth sedative. Domperidone possesses both prokinetic and antiemetic properties. Domperidone is a dopaminergic and it is postulated that it causes antiemetic action by blocking dopamine receptors, also it increases gastric motility. Domperidone crosses the blood brain barrier to only a limited extent, and it causes extra pyramidal side effects very rarely.
Pharmacokinetics:
Cinnarizine is absorbed from the gastro intestinal tract, peak plasma concentrations occurring 2 to 4 hrs after oral administration. It undergoes metabolism and has a half life of 3 to 6 hrs. Cinnirazine is excreted mainly in the feces as unchanged drug and in urine mainly as its metabolites. Domperidone bioavailability is increased when it is administered after food compared to before food. Peak plasma is reached within 30 minutes following the administration of dose, 90% is bound to plasma protein and has a half life is 7.5 hrs. About 30% of the dose is excreted in urine within 24 hrs almost entirely as metabolites and the remaining as feces over several days.

Interactions

● CNS depressant effect of cinnarizine is enhanced with alcohol.
● Domperidone reduces absorption of oral digoxin. It increases absorption of aspirin, paracetamol and oral diazepam.
● Enhances CNS depression by phenothiazine.
● Antimuscarinic agents and opioids antagonise GI effects. Prolongs suxamethonium-induced neuromuscular blockade.

Warnings

●This medicine may lead to drowsiness and impaired concentration, which may be aggravated by simultaneous intake of alcohol or other central nervous system depressants.
● Patients should not operate hazardous machinery or drive motor vehicles or perform potentially hazardous tasks where loss of concentration may lead to accidents.

Dosage

Oral
This is Preferred Dosage:
Motion sickness
Adult: Each tablet contains cinnarizine 20 mg and domperidone 15 mg: 1 tablet taken 1-2 hours before travel and 1 tablet every 6 hours during journey if necessary.
Disclaimer:To be taken only after consulting with the doctor.

Storage

Keep all medicines out of the reach and sight of children. Store in a cool,dry place, away from direct heat and light.

Contact Details

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