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Dextromethorphan HBR 10 mg, CPM 2 mg, Phenylephrine HCL 5 mg Syrup


  • Cough and cold, Allergic rhinitis

Mechanism of Action

Chlorpheniramine is an H1 antagonist and is used in allergic reaction, hay fever, rhinitis, urticaria, and asthma. It reduces the histamine production thereby preventing classical symptoms such as itchy and runny nose, watery eyes.

Phenylephrine is a sympathomimetic amine that acts predominantly on α-adrenergic receptors. It is mainly used to treat nasal congestion;.It causes vasoconstriction in the mucosa of the respiratory tract leads to decreased oedema and increased drainage of sinus cavities, hence providing relief from stuffy nose and sinus pressure.

Dextromethorphan which is an antitussive (cough suppressant) and provides temporary relief of cough ,It acts on the cough centre in medulla of the brain.


  • Should be used in caution with patients with gastric ulcer.
  • Use cautiously with pregnancy, lactation, and persistent coughs.
  • Use drug with caution in patients with cirrhosis or other liver disease.
  • It should not be used in patients hypersensitive to any active ingredient.
  • It should not be used in patients severe hypertension, ventricular tachycardia,

Warning & Precautions

  • Monitor patient for dizziness and excessive drowsiness. If noted, hold therapy and notify health care provider.
  • Use with caution in elderly patients, usually starting at the low end of the dosage range because of the greater frequency of decreased hepatic, renal, or cardiac function, and concomitant diseases or other drug therapy.

Drug Interactions

Chlorpheniramine may cause additional CNS depressant action. It should not be used with Alcohol, CNS depressants, and tricyclic antidepressants.

Monoamine oxidase inhibitors may increase the anti cholinergic effects of Chlorpheniramine.
Allergic reactions such as skin rash, nettle-rash, and angioneurotic oedema are possible. Under the prolonged administration in large doses pain in epigastrial area, nausea, vomiting can appear
Patients using the following medicines should use dextromethorphan with caution, celecoxib, imatinib , quinidine, ranolazine, ritonavir, sibutramine, terbinafine.

Undesirable Effects

  • Drowsiness due to Chlorpheniramine, sedation ; slow, shallow breathing.


CNS depression (including sedation, apnea, CV collapse), CNS stimulation (including insomnia, hallucination, tremors, convulsions), tinnitus, blurred vision, dizziness, ataxia, hypotension. Stimulation and atropine-like signs and symptoms (including dry mouth, fixed dilated pupils, flushing, hyperthermia, GI symptoms) are more likely in children.
Overdosage may induce ventricular extrasystoles and short paroxysms of ventricular tachycardia, a sensation of fullness in the head and tingling of the extremities.
Should an excessive elevation of blood pressure occur, it may be immediately relieved by an α– adrenergic blocking agent (e.g., phentolamine).Blurred vision, confusion, difficulty in urination, drowsiness or dizziness, nausea or vomiting (severe), shakiness and unsteady walk, slowed breathing, unusual excitement, nervousness, restlessness, or irritability


The combination is well established in patients with cold and cough.


Chlorpheniramine Maleate:
Absorption and distribution: It is absorbed relatively slowly from the gastrointestinal tract, with peak plasma concentrations occurring about 2.5 to 6 hours after oral administration. Chlorpheniramine appears to undergo considerable first-pass metabolism. Bioavailability is low, values of 25 to 50% having been reported. About 70% of chlorpheniramine in the circulation is bound to plasma proteins. There is wide inter-individual variation in the pharmacokinetics of chlorpheniramine; half-life values ranging from 2 to 43 hours have been reported. Chlorpheniramine is widely distributed in the body and enters the CNS.
Metabolism: Chlorpheniramine maleate is metabolised extensively. Metabolites include desmethyl- and didesmethylchlorpheniramine. Unchanged drug and metabolites are excreted primarily in the urine; excretion is dependent on urinary pH and flow rate. Only trace amounts have been found in the faeces.
Excretion: A duration of action of 4 to 6 hours has been reported; this is shorter than may be predicted from pharmacokinetic parameters.
Phenyleprine Maleate:
Oral absorption of Phenylephrine (HCl) is found to be 73% ±2. Volume of distribution is found to be 340 litre . Presystemic metabolism is noted to be 60% and metabolism is reported Hepatic. Renal Excretion accounts for < 20 % and plasma half life is 2 - 3 hr.

Dextromethorphan hydrogen bromide:
Dextromethorphan is rapidly absorbed from the gastrointestinal tract and peak plasma concentrations are reached in approximately 2.5 hours. Dextromethorphan is widely distributed, and is rapidly and extensively metabolized by the liver. Dextromethorphan is demethylated to dextrorphan, an active metabolite, and to 3-methoxymorphinan and 3-hydroxymorphinan. It is primarily excreted as unchanged parent drug and dextrorphan.

Shelf Life

2 years
The preparation should not be used after the expiry date.


Store below 30°C. Protect from light & moisture.
Keep it out of reach of children

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