These tablets are used to control sugar level in the blood and are highly demanded in the market due to fast relief and effectiveness. This tablet contains two oral anti – hyperglycemic drugs Gliclazide and Metformin HCl used in the management of type 2 diabetes, which has not come under control by diet and exercise alone.
- Quick result
- Accurate composition
- Long shelf life
Mechanism of Action
Metformin restores body's ability to use insulin to lower blood sugar level. Also, decreases amount of glucose absorbed from food in the intestine and decreases glucose production from liver.
Gliclazide appears to be useful in both macro-vascular & micro-vascular complications, which occurs due to either hyperinsulinaemia, hypertens ion, hyperglycaemia, hyperlipidaemia, platelet aggregation.
Metformin is associated with a decrease in fast ing & postprandial plasma insulin & triglyceride levels, increase in HDL-cholesterol, increase of tissue plasminogen activator, decrease in platelet aggregation.
Gliclazide is extensively metabolized to 7 metabolites predominantly excreted in the urine, the most abundant being the carboxylic acid derivative; 60-70% of the dose is excreted in the urine and 10-20% in the faeces.
Metformin has absolute oral bioavailability of 50-60%. GIT absorption is complete within 6 hrs of ingestion within metformin is rapidly distributed in body after absorption. The renal elimination of metformin is biphasic. 95% of the absorbed metformin is eliminated during primary elimination phase having half-life of 6 hours. Rest of the 5% is eliminated during slow terminal elimination phase with mean half-life of 20 hours. Metformin is not bound to plasma proteins; 40-60% of the dose is recovered as unchanged drug in urine with a further 30% recovered as unchanged drug in faeces.
Dermatological effects – Rash, pruritus, urticaria, erythema and flushing.
Miscellaneous – Headache and dizziness.