Levocetirizine Dihydrochloride Tablet is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Levocetirizine Hcl works by blocking the actions of histamine. Levocetirizine Hcl is used to treat symptoms of perennial allergies in adults and children who are at least 6 months old. Levocetirizine Hcl is also used to treat symptoms of seasonal allergies in adults and children who are at least 2 years old and it is also used to treat itching and swelling caused by chronic urticaria (hives) in adults and children who are at least 6 months old.
Indications and Usage
- Allergic Rhinitis: Levocitrizine is indicated for the relief of symptoms associated with allergic rhinitis (seasonal and perennial) in adults and children 6 years of age and older.
- Chronic Idiopathic Urticaria: Levocitrizine is indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children 6 years of age and older.
Absorption: Rapidly and extensively absorbed. T max is 0.9 h. C max is 270 and 308 ng/mL after single and repeated once-daily dosing, respectively. Steady state achieved after 2 days.
Distribution: Plasma protein binding about 92%. Vd is approximately 0.4 L/kg.
Metabolism:Metabolism is less than 14% and by aromatic oxidation, N- and Odealkylation, and taurine conjugation.
Elimination: The t ½ is about 8 to 9 h. Elimination is 85.4% and 12.9% via urine and feces, respectively. Excreted both by glomerular filtration and active tubular transport.
Mode of Action
● Dry Mouth
Driving & Using machineries
"However, this information is relevant to the active Ingredients, Levocetirizine dihydrochloride."
"Caution when driving or operating machinery."
"Response to medication may vary from one individual to another, contain side effects like (vertigo, dizzies nervousness, insomnia) that have been reported very rarely with the medicine may affect some patient's ability to drive, operate machinery."
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