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UMECO-VIT

₹165

Mecobalamin 1500 mcg, Alphaliphoic Acid 100 mg,
Folic Acid 0.2 mg, Vitamin B1 1.4 mg Capsules


This combination is used to treat several central nerve disorders & provides energy.

Indications

  • Megaloblastic anemia
  • Used to treat folate deficiency anemia
  • Sideroblastic anemia

About Combination

Mecobalamin:
it is the form of vitamin B which helps in the production of myelin, a substance that protects nerve fibers from damage and rejuvenates the damaged nerve cells.
ALA:
alanine is the amino acid which is necessary for the synthesis of the protein. It is produced from the pyruvate by transamination . It increases immunity , provides energy.
Folic acid:
 Folic acid is the part of the vitamin -B family . It is water soluble vitamin . It  helps your body produce and new cells, and also helps to prevent changes in the DNA that may lead to cancer.
Pyridoxine:
Pyridoxine has been used to treat or prevent certain nerve disorder like peripheral neuropathy caused by certain medications such as isoniazid . It has also been used to treat certain hereditary disorders such as xanthurenic aciduria, excessive urine excretion of the oxalate. It is one of the major component required by red blood cells.

Mechanism of action

Mecobalamin:
Mecobalamine acts to repair nerve damage occurs due to nerve disorders . Mecobalamin act as the cofactor for the synthesis of methionine synthase which converts homocysteine to mecobalamin thus lowers the blood vessels level of homocysteine .
ALA:
branched chain amino acid is produced from the skeletal muscles and its carbon moiety is serve as fuel whereas nitro group serve as for the production of the other amino acid alanine . Alanine is then converted to glucose into the liver and provide energy .
Folic acid:
folic acid is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase this congeners are transported by endocytosis to maintain normal erythropoiesis for the production of the purines and pyrimidines.
Pyridoxine:
it is converted into pyridoxal 5 - phospahte which is responsible for the production of amino acid , hemoglobin , sphingomyelin and involved in the synthesis of neurotransmitter serotonin , dopamine , norepinephrine and gamna aminobutyric acid.

Pharmacokinetics

Folic acid:
Absorption: It is rapidly absorbed from the small intestine.
Protein binding: It is highly bound to plasma protein.
Metabolism: It is metabolized into tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase.
Excretion: It is excreted via urine.

Pyridoxine:
Absorption: It is rapidly absorb from the GIT.
Protein binding: It is highly bound to serum albumin.
Metabolism: It is metabolized in the liver to 4- pyridoxic acid.
Excretion: It is excreted via urine.

Side Effects

  • Diarrhea
  • Gastrointestinal disturbances
  • Stomach upset
  • Headache
  • Drowsiness
  • Hypersensitivity

Contraindication

Contraindicated in people with known hypersensitivity.

Storage

Store it at 15ºC to 30ºC.

Contact Details

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