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INQUFLOX 200 MG

₹57.50

Ofloxacin 200 mg Tablets


Ofloxacin is a synthetic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone. Ofloxacin is a quinolone carboxylic acid derivative which has a broad spectrum of antibacterial activity against both Gram-positive and Gram-negative bacteria. It kills sensitive bacteria by stopping the production of essential proteins needed by the bacteria to survive.

What is INQUFLOX 200 MG and what it is used for?
Ofloxacin tablets are a synthetic broad-spectrum antimicrobial agent for oral administration. Ofloxacin has a bactericidal effect. In vitro tests show that strains in which thesensitivity varies include pneumococci andureaplasma urealyticum. Strains that are normally resistant are: Peptococcus, Peptostreptococcus, Eubacterium spp., Fusobacterium spp. and Treponema pallidum.

Indications and Usage

Ofloxacin is indicated for the treatment of the following bacterial infections if these are due to ofloxacin-sensitive pathogens:
  • Lower respiratory tract infections caused by Haemophilus influenzae, Haemophilus parainfluenzae, Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis and Pseudomonas aeruginosa.
  • Infections of the urinary tract.
  • Sexually transmitted diseases; Acute uncomplicated urethral and cervical gonorrhoea, urethritis and cervicitis due to Chlamydia trachomatis. Mixed infections of the urethra and cervix due to Chlamydia trachomatis and Neisseria gonorrhoea.

For Professionals

Ofloxacin is a quinolone carboxylic acid derivative which has a broad spectrum of antibacterial activity against both Gram-positive and Gram-negative bacteria. Ofloxacin exerts its effect by inhibiting the bacterial DNA gyrase, which is responsible for coiling the genetic material as a prerequisite for bacterial multiplication.The mode of action, range of activities, duration of action and MIC levels have been established mainly by means of in vitro studies using bacterial isolates. Ofloxacin is readily absorbed and excreted mainly unchanged in the urine. The serum elimination half-life is approximately 6 to 8 hours.
Following oral administration, ofloxacin peak serum concentrations are reached within one to two hours. The plasma level usually achieved by the recommended dosage regimens (3 to 4 micrograms/mL) is in excess of the average MIC which is 1 to 2 micrograms/mL, for susceptible organisms. Ofloxacin has a low (9,4%) plasma protein binding. Ofloxacin has a bactericidal effect. In vitro tests show that strains in which the sensitivity varies include pneumococci and ureaplasma urealyticum.
Strains that are normally resistant are:
Peptococcus, Peptostreptococcus, Eubacterium spp., Fusobacterium spp. and Treponema pallidum.

WHAT OTHER DRUGS WILL AFFECT OFLOXACIN?
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with ofloxacin, especially:
• Theophylline
• A diuretic or "water pill"
• Heart rhythm medication--amiodarone, disopyramide, dofetilide, dronedarone, procainamide, quinidine, sotalol, and others
• Medicine to treat depression or mental illness--amitriptylline, clomipramine, clozapine, desipramine, duloxetine, iloperidone, imipramine, nortriptyline, ziprasidone, and others
• NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

Interactions

Tell your doctor especially if you or your child are taking or using any of the following medicines:
• Allopurinol or probenecid (for treatment of gout)
• Anticoagulants (used to prevent blood clots) such as warfarin
• Mycophenolate mofetil (suppressed the immune system)

Dosage

Oral:
This is Preferred Dosage:
Adult: Based on amoxicillin dose, 250-500 mg every 8 hours or 500-750 mg every 12 hours.
Child: Based on amoxicillin dose: 125-250 mg every 8 hours.
Children weighing <40 kg: 20-40 mg/kg/day in divided doses every 8 hours.
Infants <3 months: up to 30 mg/kg/day in divided doses every 12 hours.

Disclaimer:To be taken only after consulting with the doctor.

The following dosages are recommended:
Uncomplicated Cystitis: 100 mg twice daily for 3 - 7 days.
Pyelonephritis: 200 mg twice daily for 5 - 7 days.
For patients with impaired renal function and elderly patients, the dosage of ATMOFLOX Tablets should be adjusted according to the degree of impairment. With a creatinine clearance of less than 50 mL to 20 mL/minute, a normal single dose should be administered every 24 hours, e.g. 200 mg once daily.
With a creatinine clearance of less than 20 mL/minute, the normal single dose should be given initially. This dose should then be reduced to half and administered every 24 hours, e.g. 200 mg initially, thereafter 100 mg once daily.

Warnings

Clostridium difficile - associated disease:
Diarrhoea, particularly if severe and/or persistent, occuring during treatment or in the initial weeks following treatment with ofloxacin or with various other antibiotics, but especially broad spectrum antibiotics, may be sympomatic of Clostridium difficile-associated disease, the most severe form of which is pseudo-membranous colitis.
If a diagnosis of pseudomembranous colitis is suspected, ofloxacin should be stopped immediately and appropriate specified antibiotic therapy should be started without delay (e.g. vancomycin or metronidazole).
Tendinitis, less frequently observed, may occasionally lead to rupture, involving more particularly Achilles tendon, and occurring especially in elderly patients. Rupture seems to be favoured by treatment with corticosteroids. The onset of signs of tendinitis requires to stop the treatment, to rest both Achilles tendons by appropriate immobilisation or special heel pieces, and to take orthopaedic advice.
Ofloxacin may aggravate myasthenia gravis.Ofloxacin may negativate the isolation of Mycobacterium tuberculosis, giving falsenegative results, in the bacteriological diagnosis of tuberculosis.
The serum concentration of ofloxacin should be monitored in patients with severe renal impairment and haemodialysis patients. Although this has not been reported, the possibility cannot be ruled out that fluoroquinolones may trigger an attack of porphyria in predisposed patients.

Storage

Store below 25 degree celcius in a dry place.
Protect from light.
Keep in the pack until required.
Do not use later than the date of expiry.
KEEP OUT OF REACH OF CHILDREN.

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