It has been demonstrated by recent studies from International Journal of Medical Research & Health Sciences studies of Mefenamic Acid, paracetamol shows better symptom relief compared with other formulations.
Main features:Fever, Muscle Pain, Sciatica.
Mefenemic Acid:Absorption:oral absorption of mefenamic acid is found to be 92.5%.
Distribution:volume of distribution is found to be 1.3 l/kg and plasma protein binding is 99%.
Metabolism:metabolism is reported Hepatic via enzyme CYP2C9.
Excretion:renal excretion accounts for 70% and plasma half life is 3-4 hr.
Paracetamol:Absorption:oral absorbed from the gastrointestinal tract ranging from 70 to 90%. Paracetamol is also well absorbed from the rectum.
Distribution:It distributes rapidly and evenly throughout most tissues and fluids and has a volume of distribution of approximately 0.9L/kg. 10 to 20% of the drug is bound to red blood cells.
Metabolism:Paracetamol is extensively metabolized (predominantly in the liver), the major metabolites being the sulphate and glucuronide conjugates.
Excretion:A minor fraction of drug is converted to a highly reactive alkylating metabolite and excreted in the urine as cysteine and mercapturic acid conjugates.
Mefenamic Acid:Mefenamic Acid enhances activity of oral anticoagulants but rarely significant. Increases risk of GI irritation with alcohol. Increased ciclosporin, lithium toxicity and convulsions reported with ciprofloxacin. Absorption increased by magnesium hydroxide antacids. ACE inhibitor effects may be antagonized.
Paracetamol:Absorption of paracetamol is increased by concomitant metoclopramide, and such other agents. Probenecid can decrease it's clearance whilst cholestyramine diminishes absorption of paracetamol when co administered.
- Feeling or being sick
- Hypersensitivity reactions
- Skin rashes
"Response to medications may vary from one individual to another, contain side effects like (dizziness, vomits) that have been reported very rarely with the medicine may affect some patient's ability to drive, operate machinery."