Terbinafine (HCl) is antifungal agent, it is a synthetic allylamine and available as oral and topical formulation. Oral terbinafine is highly effective for treating onychomycosis due to its fungicidal activity and ability to concentrate within the nails. It was developed by Novartis. It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. The U.S. Food and Drug Administration approved the first generic versions of terbinafine hydrochloride tablets. On September 28, 2007, FDA approved the use of terbinafine hydrochloride use in children of age 4 and above.
They are potent fungicidal agents as it inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (squalene 2,3-epoxidase), an enzyme that is part of the fungal cell wall synthesis pathway, thereby removing the fungal infection from the root level. It is useful in various fungal disorders such as Athelets foot, Dermatophyte infections of the nails, Hair and nail infection, scalp Ringworm, Tinea corporis, Tinea cruris, Tinea pedis.
Indications & Usage
Mechanism of Action
Pharmacokinetic:Absorption: Absorbed well from the GI tract with 40% bioavailability (oral), minimal absorption (topical); peak plasma concentrations after 2 hours (oral).
Distribution: Distributed into stratum corneum of the skin, nail plate, hair (concentrations higher than plasma) and breastmilk.
Metabolism: Hepatic; converted to inactive metabolites.
Excretion: Via urine; 17-36 hours (plasma elimination half-life); up to 400 hours (terminal elimination half-life) in prolonged therapy.
- Caution when used during pregnancy
- Safety and efficacy not established in children younger than 4 years of age.
Warning & Precautions
Patients prescribed Terbinafine Hydrochloride Tablets should be report immediately to their physician of any symptoms of persistent nausea, anorexia, fatigue, vomiting, right upper abdominal pain or jaundice, dark urine or pale stools. Patients with these symptoms should discontinue taking oral Terbinafine, and the patient's liver function should be immediately evaluated.