Mechanism Of Action
Xylometazoline is an imidazole derivative which is designed to mimic the molecular shape of adrenaline. It binds to alpha-adrenergic receptors in the nasal mucosa. Due to its sympathomimetic effects, it should not be used by people with high blood pressure, or other heart problems.
Benzalkonium chloride is highly soluble in water, it is a quaternary ammonium (cationic) antiseptic These are detergents and have bactericidal, fungicidal properties. They act by altering permeability of cell membranes and denaturing of bacterial proteins. They are non irritating and mildly keratolytic. They are widely used as sanitizers, antiseptic and disinfectant for surgical instruments etc. A 1:1000 solution is used for sterile storage of instruments and 1 in 5000 to 1 in 10,000 for douches, irrigation etc.
Benzalkonium chloride solution is an aqueous solution of a mixture of alkylbenzyldimethylammonium chlorides, the alkyl groups having chain lengths of C8 to C18.
Pharmacodynamics:The combination is usually well tolerated in nasal decongestion.
Pharmacokinetics:Xylometazoline is a direct-acting sympathomimetic which has a vasoconstrictor effect by reducing swelling and congestion when applied to mucous membranes.
Onset of action 5-10 minutes, Duration stays for 10 hours.
It may be contraindicated in patients who are hypersensitive to any ingredient.